Pyroglutamyl-peptidase I

Pyroglutamyl-peptidase I (, also known as Pyrrolidonyl peptidase, is an enzyme (a cysteine peptidase) found in bacteria, plants and animals.

It can be used to distinguish certain Streptococcal organisms.

Other names are 5-oxoprolyl-peptidase, pyrase, pyrrolidonyl arylamidase, pyroglutamate aminopeptidase, pyroglutamyl aminopeptidase, L-pyroglutamyl peptide hydrolase, pyrrolidone-carboxyl peptidase, pyrrolidone-carboxylate peptidase, pyrrolidonyl peptidase, L-pyrrolidonecarboxylate peptidase, pyroglutamidase, pyrrolidonecarboxylyl peptidase) is an enzyme.   This enzyme catalyses the following chemical reaction


 * Release of an N-terminal pyroglutamyl group from a polypeptide, the second amino acid generally not being Pro

Human gene
PGPEP1