R53

R53 may refer to:
 * R53 (South Africa), a road
 * HMS Undaunted (R53), a destroyer of the Royal Navy
 * Junkers R53, a transport aircraft
 * Mini Hatch (R53), a car
 * Nissan Pathfinder (R53), a sport utility vehicle
 * R53: May cause long-term adverse effects in the aquatic environment, a risk phrase
 * Tachihi R-53, a training aircraft