RAB27A

Ras-related protein Rab-27A is a protein that in humans is encoded by the RAB27A gene.

Function
The protein encoded by this gene belongs to the small GTPase superfamily, Rab family. The protein is membrane-bound and may be involved in protein transport and small GTPase mediated signal transduction. Mutations in this gene are associated with Griscelli syndrome type 2 and hemophagocytic lymphohistiocytosis. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified.

The RAB27A gene is regulated by the Microphthalmia-associated transcription factor.

Interactions
RAB27A has been shown to interact with:


 * EXPH5,
 * MYO5A,
 * RPH3AL
 * SYTL1,  and
 * SYTL2.