RLE

RLE may refer to:


 * Run-length encoding, a form of lossless data compression
 * Radical life extension, a study to extend human lifespan
 * Right-to-left embedding, in bi-directional text
 * Refractive lens exchange, an eye operation
 * Real-life experience (transgender), a period of time in which transgender individuals live full-time in their preferred gender role
 * Rail Logistics Europe, the rail freight and logistics operations division of SNCF