RNF40

E3 ubiquitin-protein ligase BRE1B is an enzyme that in humans is encoded by the RNF40 gene.

Function
The protein encoded by this gene contains a RING finger, a motif known to be involved in protein-protein and protein-DNA interactions. This protein was reported to interact with the tumor suppressor protein RB1. Studies of the rat counterpart suggested that this protein may function as an E3 ubiquitin-protein ligase, and facilitate the ubiquitination and degradation of syntaxin 1, which is an essential component of the neurotransmitter release machinery.

Interactions
RNF40 has been shown to interact with STX1A.