RS1

RS1 or RS-1 may refer to:
 * ALCO RS-1, a 4-axle diesel-electric locomotive built by Alco-GE and later by Alco alone
 * K-5 (missile), also known as RS-1U or product ShM, an early Soviet air-to-air missile
 * The Reid and Sigrist R.S.1, a British twin-engined, three-seat advanced trainer developed during World War II
 * Retinoschisin, a protein that in humans is encoded by the RS1 gene
 * Ross RS-1 Zanonia, a single seat, gull-winged glider
 * RS-1, an Indian satellite in the Rohini (satellite) series
 * (7080) 1986 RS1, generally written as (7080) 1986 RS1, a main-belt minor planet
 * Sikorsky S-41, an amphibious flying boat airliner designated by the U.S. Navy as RS-1
 * Stadler Regio-Shuttle RS1, a diesel railcar manufactured by Stadler Rail AG
 * Goodyear RS-1 America's first semi-rigid airship
 * RS/1, statistical software from Bolt, Beranek and Newman
 * The first Randall–Sundrum model
 * ABL Space Systems RS1, a planned liquid-fuelled small-lift launch vehicle
 * RS1, a type of resistant starch