RSE

RSE may refer to:
 * Ramtha's School of Enlightenment, a spiritual school in the United States
 * Realistic Sound Engine, a sound output format in Guitar Pro
 * Red Seal Endorsement, post-nominal letters signifying attainment of Canada's official journeyperson certification in the trades
 * Relationship and Sex Education, an education curriculum in United Kingdom schools
 * Red Storm Entertainment, a video game company
 * Refractory status epilepticus, the persistent form of status epilepticus despite intervention
 * Relative standard error, a measure of a statistical estimate's reliability
 * Rensselaer Society of Engineers, a local fraternity at Rensselaer Polytechnic Institute, state of New York
 * Research software engineering, the use of software engineering practices in research
 * Rhein-Sieg-Eisenbahn, a German railway company
 * the IATA airport code of Rose Bay Water Airport, a water airport located in the suburb of Rose Bay in Sydney, Australia
 * Royal Society of Edinburgh, Scotland's national academy of science and letters
 * Rwanda Stock Exchange, a stock exchange in Rwanda
 * Pokémon Ruby and Sapphire and Pokémon Emerald, the three main titles of the third generation of the Pokémon series
 * Rainbow Shared Energy Company Limited