Ras-interacting protein 1

Ras-interacting protein 1 (Rain), is a protein that in humans is encoded by the RASIP1 gene.

Function

 * It is required for the proper formation of vascular structures that develop via both vasculogenesis and angiogenesis.
 * Acts as a critical and vascular-specific regulator of GTPase signaling, cell architecture, and adhesion, which is essential for endothelial cell morphogenesis and blood vessel tubulogenesis.
 * Regulates the activity of Rho GTPases in part by recruiting ARHGAP29 and suppressing RhoA signaling and dampening ROCK and MYH9 activities in endothelial cells.

Clinical significance
A recent genome-wide association study (GWAS) has found that genetic variations in RASIP1 are associated with late-onset sporadic Alzheimer’s disease (LOAD). However, it's unknown how RASIP1 mutation contributes to disease.