Region 2

Region 2 or Region II may refer to:


 * Region 2, Northwest Territories (Canadian census)
 * The Midwest of the US (American census)
 * Former Region 2 (Johannesburg), an administrative district in Johannesburg, South Africa, from 2000 to 2006
 * Antofagasta Region, Chile
 * Cagayan Valley (Region II), Philippines
 * ITU Region 2, consisting of the Americas
 * One of the DVD regions
 * One of the health regions of Canada, managed by Horizon Health Network
 * One of the regions of Iran