Route 59 (disambiguation)

Route 59 may refer to:


 * Route 59 (MTA Maryland), a bus route in Baltimore, Maryland and its suburbs
 * London Buses route 59
 * Melbourne tram route 59
 * SEPTA Route 59, a trackless trolley in Northeast Philadelphia
 * Route 59 (Metra), a train station along the BNSF Railway Line on the border of Aurora, Illinois and Naperville, Illinois