São Francisco do Guaporé

São Francisco do Guaporé is a municipality located in the Brazilian state of Rondônia. Its population was 20,681 (2020) and its area is 10,960 km2.

The municipality contains 9% of the 36442 ha Serra dos Reis State Park. It contains 86% of the 2244 ha Serra dos Reis A State Park, created in 1996. It holds part of the 615771 ha Guaporé Biological Reserve, a strictly protected conservation unit.