São Tomé and Príncipe at the 2020 Summer Olympics

São Tomé and Príncipe competed at the 2020 Summer Olympics in Tokyo. Originally scheduled to take place from 24 July to 9 August 2020, the Games have been postponed to 23 July to 8 August 2021, because of the COVID-19 pandemic. It was the nation's seventh consecutive appearance at the Summer Olympics.

Competitors
The following is the list of number of competitors in the Games.

Athletics
São Tomé and Príncipe received a universality slot from the World Athletics to send a female track and field athlete to the Olympics.


 * Key
 * Note–Ranks given for track events are within the athlete's heat only
 * Q = Qualified for the next round
 * q = Qualified for the next round as a fastest loser or, in field events, by position without achieving the qualifying target
 * NR = National record
 * N/A = Round not applicable for the event
 * Bye = Athlete not required to compete in round


 * Track & road events

Sprint
São Tomé and Príncipe qualified a single boat (men's C-2 1000 m) for the Games by winning the gold medal at the 2019 African Games in Rabat, Morocco.

Qualification Legend: FA = Qualify to final (medal); FB = Qualify to final B (non-medal)