S-phase kinase-associated protein 1

S-phase kinase-associated protein 1  is an enzyme that in humans is encoded by the SKP1 gene.

This gene encodes a protein that is a member of the SCF ubiquitin ligase protein complex. It binds to F-box proteins (proteins containing an F-box motif), such as cyclin F, S-phase kinase-associated protein 2, and other regulatory proteins involved in ubiquitin dependent proteolysis. The encoded protein also collaborates with a network of proteins to control beta-catenin levels and affects the activity level of beta-catenin dependent TCF transcription factors. Studies have also characterized the protein as an RNA polymerase II elongation factor. Alternative splicing of this gene results in two transcript variants. A related pseudogene has been identified on chromosome 7.

Interactions
SKP1A has been shown to interact with:


 * BTRC,
 * CACYBP,
 * CDCA3,
 * CDK9,
 * CUL1,
 * FBXL3,
 * FBXO4,
 * FBXO5,
 * FBXO7,
 * FBXW2,
 * FBXW7, and
 * SKP2.