S. spinosa

S. spinosa may refer to:
 * Saccharopolyspora spinosa, a bacterium species in the genus Saccharopolyspora
 * Scaphiophryne spinosa, a frog species
 * Seddera spinosa, a plant species endemic to Yemen
 * Sida spinosa, a plant species in the genus Sida endemic to Hawaii
 * Smilax spinosa, a climbing flowering plant species in the genus Smilax
 * Stasina spinosa, a spider species in the genus Stasina
 * Stephanomeria spinosa, a wirelettuce species in the genus Stephanomeria
 * Strychnos spinosa, a tree species