S100

S100 or S-100 may refer to:
 * S-100 bus, an early computer bus
 * S-100, an International Hydrographic Organization standard
 * S100 protein, low-molecular-weight proteins in vertebrates
 * The road number used in the Netherlands for inner-city ring roads
 * AVE Class 100, or S100, a high speed train
 * Canon PowerShot S100, a camera
 * Colyaer Freedom S100, a Spanish amphibious ultralight aircraft
 * Colyaer Gannet S100, a Spanish ultralight flying boat
 * Colyaer Martin3 S100 is a Spanish ultralight aircraft
 * A class of WWII German E-Boat.
 * Guild S-100, an electric guitar
 * Lenovo IdeaPad S100, a netbook computer
 * Qtek S100, a mobile phone
 * Schiebel Camcopter S-100, an unmanned aerial vehicle
 * Škoda 100, a 1970s car
 * USATC S100 Class, a 1942 steam locomotive class