S22

S22 may refer to:

Aviation

 * Hermiston Municipal Airport, in Umatilla County, Oregon, United States
 * Letov Š-22, a prototype Czechoslovak fighter
 * SIAI S.22, an Italian racing flying boat
 * Sikorsky S-22, a Russian trainer

Rail and transit

 * S22 (RER Vaud), an S-Bahn line in Switzerland
 * S22 (ZVV), a former Zürich S-Bahn line
 * Kozawa Station, in Kyōwa, Hokkaidō, Japan
 * Shōji Station (Osaka, Osaka), in Japan

Roads

 * Expressway S22 (Poland)
 * County Route S22 (California), United States

Submarines

 * BRAZILIAN SUBMARINE Riachuelo
 * CHILEAN SUBMARINE O'Brien
 * HMS Resolution (S22), of the Royal Navy
 * INS Khanderi (1968), of the Indian Navy
 * INS Khanderi (2017), of the Indian Navy
 * USS S-22 (SS-127), of the United States Navy

Other uses

 * British NVC community S22, a swamps and tall-herb fens community in the British National Vegetation Classification system
 * Karry S22, a Chinese MPV
 * S22: Do not breathe dust, a safety phrase
 * Samsung Galaxy S22, a series of smartphones
 * Sisu S-22, a Finnish lorry