S2P

S2P may refer to:

Biochemistry

 * Membrane-bound transcription factor peptidase, site 2, an enzyme

Computing

 * S2P File Format, a Touchstone File format for 2-port S-parameters
 * S$P 2$, a complexity class expressing "symmetric alternation"
 * Microsoft Surface Pro 2, a Surface-series Windows 8 tablet

UK Pensions

 * State Second Pension