S46

S46 may refer to:

Submarines

 * HMS Churchill (S46), of the Royal Navy
 * INS Shalki (S46), of the Indian Navy
 * USS S-46 (SS-157), of the United States Navy

Other uses

 * S46 (Berlin), a line of the Berlin S-Bahn
 * S46 (New York City bus), serving Staten Island
 * Blériot-SPAD S.46, a French biplane airliner
 * Explorer S-46 (satellite), a failed American spacecraft
 * GER Class S46, a British steam locomotive
 * Parti Melayu Semangat 46, a defunct political party in Malaysia
 * S46: If swallowed, seek medical advice immediately and show this container or label, a safety phrase
 * SABCA S-46, a Belgian aircraft
 * Sulfur-46, an isotope of sulfur