S49

S49 may refer to:
 * County Route S49 (Bergen County, New Jersey)
 * Ikarus S-49, a Yugoslav fighter aircraft
 * Miller Memorial Airpark, in Malheur County, Oregon, United States
 * New Jersey Route 47, partially designated Route S49 until 1953
 * S49: Keep only in the original container, a safety phrase
 * USS S-49 (SS-160), a submarine of the United States Navy
 * S49, a postcode district in Chesterfield, England