SC-6

SC-6 or variant may refer to:


 * South Carolina's 6th congressional district
 * SC6 spodumene concentrate 6, a high-purity refined ore of lithium for battery manufacture
 * SC 6, an abbreviation for South Carolina Highway 6
 * Strathcarron SC-6, a British sports car; see Strathcarron Sports Cars
 * USS SC-6, a United States Navy submarine chaser commissioned in 1918 and sold in 1921
 * SC06, a FIPS 10-4 region code, see List of FIPS region codes (S–U)
 * SC-06, a subdivision code for the Seychelles, see ISO 3166-2:SC
 * SC6, the former branding of the 6:00 p.m. ET edition of ESPN's SportsCenter hosted by Jemele Hill and Michael Smith
 * Soulcalibur VI, a fighting game published by Bandai Namco Entertainment