SC1

SC1 or SC-1 may refer to:
 * South Carolina's 1st congressional district
 * USS SC-1, a United States Navy submarine chaser commissioned in 1917 and sold in 1921
 * SC-01 speech synthesizer by Votrax
 * SC01, a FIPS 10-4 region code, see List of FIPS region codes (S–U)
 * SC-01, a subdivision code for the Seychelles, see ISO 3166-2:SC

Video games

 * The first title in the StarCraft series.
 * The first title in the SimCity series
 * The first title in the Tom Clancy's Splinter Cell series

Aircraft

 * Signal Corps Dirigible No. 1 A 1908 Dirigible built by Thomas Scott Baldwin
 * Curtiss SC-1 Seahawk, a version of the American Curtiss SC Seahawk seaplane
 * Martin SC-1, a version of the American Curtiss CS reconnaissance and torpedo bomber aircraft
 * Short SC.1, the first British fixed-wing vertical take-off and landing (VTOL) aircraft
 * Southern Cross Aviation SC-1, an Australian civil aircraft