SH2

SH2 may stand for:


 * SH2 (classification), a Paralympic shooting classification
 * SH2 domain (Src Homology 2), a protein domain within the Src oncoprotein
 * SH-2 Seasprite, an American-built ship-based helicopter
 * SH-2, an iteration of the SuperH CPU core developed by Hitachi
 * Shadow Hearts: Covenant, also known as Shadow Hearts II
 * Silent Hill 2, a 2001 survival horror video game, or its 2024 remake
 * State Highway 2, see List of highways numbered 2