SH2B1

SH2B adapter protein 1 is a protein that in humans is encoded by the SH2B1 gene.

Interactions
SH2B1 has been shown to interact with:
 * Grb2,
 * Insulin receptor,
 * Janus kinase 2, and
 * TrkA.

Clinical significance
Variations close to or in the SH2B1 gene have been found to associate with obesity in two very large genome wide association studies of body mass index (BMI). Furthermore, SH2B1 deletions are associated with severe early-onset obesity.