SMAC

SMAC may refer to:

Biology and medicine

 * Second mitochondria-derived activator of caspases or Diablo homolog, a component of the apoptosis pathway
 * Sequential Multiple Analysis - Computer or comprehensive metabolic panel, a panel of clinical chemistry lab tests
 * Supramolecular activation cluster, the structure comprising the immunological synapse

Other uses

 * Sabang Merauke Raya Air Charter, an Indonesian airline
 * Sarah McCreanor, known professionally as Smac
 * Sid Meier's Alpha Centauri, a computer game
 * Social Mobile Analytics Cloud, also called the third platform
 * Southern Maryland Athletic Conference
 * Southwestern Michigan Athletic Conference
 * Stone Mountain Arts Center, an arts center in Brownville, Maine, United States, North America
 * Supreme Macedonian-Adrianople Committee