SMO

SMO or Smo may refer to:

Biology

 * Smoothened, a gene that encodes a protein of the same name
 * Spermine oxidase, an enzyme
 * Styrene monooxygenase, an enzyme

Computing and technology

 * Sequential minimal optimization, an algorithm for training support vector machines
 * Social media optimization
 * Solar Monitoring Observatory, on the International Space Station
 * SQL Server Management Objects for Microsoft SQL Server

Organizations

 * Sabhal Mòr Ostaig, a Scottish Gaelic-medium public college on the Isle of Skye
 * Slovak Youth Orchestra

Transport

 * SMO, IATA airport code for Santa Monica Airport, USA
 * SMO, National Rail station code for South Merton railway station, London

Other uses

 * SMO, ITU country code for Samoa
 * smo, ISO 639-3 code for the Samoan language
 * Smo, former stage name of Sara Forsberg (born 1994), Finnish singer
 * SMO, a character first appeared in the episode "Be More" of the animated series Adventure Time
 * Senior Medical Officer, a rank in the British Royal Army Medical Corps
 * Singapore Mathematical Olympiad, a mathematics competition
 * Site management organization, a provider of services to an organization holding a clinical trial
 * Social movement organization, a formal organization within a social movement
 * Special military operation, the Russian government's name for the 2022 Invasion of Ukraine
 * Super Mario Odyssey, a video game released for the Nintendo Switch