SP3

SP3 may refer to:


 * sp3 hybrids, a type of orbital hybridisation
 * Sp3 transcription factor, a protein and the gene which encodes it
 * Savoia-Pomilio SP.3, a reconnaissance and bomber aircraft built in Italy
 * USS Zipalong (SP-3), an armed motorboat
 * 1971 SP3 or 3922 Heather, a main-belt asteroid discovered on September 26, 1971
 * 1984 SP3 or 3155 Lee, a main-belt asteroid discovered on September 28, 1984
 * SP3, a model of steam toy made by British manufacturer Mamod
 * Service pack 3, for computer software
 * Socket SP3, a CPU socket for AMD processors
 * SP3, a sink in the Sima Pumacocha, a cave in Peru
 * Surface Pro 3, a 2-in-1 personal computer by Microsoft