SPB

SPB may refer to:

Places

 * Saint Petersburg, Russia

Science and technology

 * Shortest Path Bridging in the IEEE 802.1aq standard
 * Slowly pulsating B star, a type of variable star
 * Spindle pole body, the functional equivalent of the mammalian centriole in yeast
 * Superpressure balloon

Transportation

 * Scappoose Industrial Airpark, Oregon, USA, FAA LID
 * Schynige Platte Bahn, a mountain railway in Switzerland
 * Charlotte Amalie Harbor Seaplane Base, U.S. Virgin Islands, IATA airport code SPB
 * Shepherd's Bush railway station, London, National Rail station code SPB

Other uses

 * Society of the Precious Blood, Anglican religious order
 * Socialist Party of Bangladesh, Political party in Bangladesh
 * S. P. Balasubrahmanyam (1946–2020), Indian playback singer, actor, music director, voice actor and film producer
 * SPB Software, mobile software developer
 * Belarus Free Trade Union, a trade union in Belarus
 * State Procurement Board in South Australia
 * Sparisjóðabanki, also known as SPB hf., a defunct bank in Iceland