SPE

SPE may refer to:

Science and technology

 * A monomer used to make polysulfobetaines, or occasionally the resulting polymer itself
 * Serum protein electrophoresis
 * Solar particle event, generating very high energy protons
 * Solid phase extraction, from a mixture
 * Solid-phase epitaxy, from amorphous to crystalline
 * The Sound Pattern of English, a 1968 book by Noam Chomsky and Morris Halle
 * SpE, abbreviation for Sporadic E propagation
 * Spe (planet), 14 Andromedae b
 * Stanford prison experiment, in psychology
 * Synchronous payload envelope, in synchronous optical networking

Computer science

 * Synergistic Processing Element in the Cell microprocessor
 * Signal-Processing Engine, for example in the PowerPC e500
 * Single-Pair Ethernet

Organizations

 * Sauber Petronas Engineering, car engine manufacturer
 * Societas Privata Europaea, a Europe-wide type of limited company
 * Sony Pictures Entertainment, a US company
 * SPE, later Luminus (company)
 * Special Police Establishment, later Central Bureau of Investigation, India
 * Special purpose entity, for a specific purpose

Professional societies

 * Society for Photographic Education
 * Society of Petroleum Engineers
 * SPE Certified Petroleum Professional, a designation
 * Society of Plastics Engineers
 * Society of Professional Engineers UK

Other

 * US supervisory patent examiner
 * SPE Certified, a food standard
 * Setiawangsa–Pantai Expressway, an expressway in Kuala Lumpur, Malaysia
 * Société Parisienne d'Édition (S.P.É.), a French publisher

Gaming

 * Seasonal Player Experience, a self imposed challenge in Realm of the Mad God