SPIE (disambiguation)

SPIE is the Society of Photo-Optical Instrumentation Engineers, an international optical engineering society.

SPIE may also refer to:
 * SPIE SA, a French industrial equipment company
 * Special Patrol Insertion/Extraction, a military technique for insertion/extraction
 * Spie Batignolles, France-based multinational engineering company
 * SPIE Gold Medal, the highest honor of the International Society for Optics and Photonics
 * SPIE Newsroom, a technical news website launched in March 2006