SPIS

SPIS may refer to:


 * Scottish Police Information Strategy, former name of the Scottish Police Services Authority – Information Communications Technology
 * Pias Airport (ICAO code), Pias, Peru
 * Spiš, a region in north-eastern Slovakia, with a very small area in south-eastern Poland
 * Spiš Castle, one of the largest castle sites in Central Europe
 * Spiš county, an administrative county of the Kingdom of Hungary