SPK

SPK may refer to:


 * SPK (band), Australia
 * SPK, Soviet cosmonaut maneuvering unit
 * Simultaneous pancreas-kidney transplant, a type of pancreas transplantation
 * Socialist Patients' Collective (German: Sozialistisches Patientenkollektiv)
 * Stiftung Preußischer Kulturbesitz, the Prussian Cultural Heritage Foundation
 * Strategic Plan Campine (Dutch: Strategisch Plan Kempen)
 * Sutton Parkway railway station's station code