SPO

SPO may refer to:

Politics

 * Serbian Renewal Movement (Srpski pokret obnove), a political party in Serbia
 * Socialist Party of Ontario, Canada
 * Strengthening Participatory Organization, a rights-based organization in Pakistan
 * SPÖ, Social Democratic Party of Austria
 * Party of Civic Rights, political party in the Czech Republic

Technology

 * Secondary phosphine oxide, a class of organophosphorus compounds
 * SharePoint Online

Other

 * Saint Paul's Outreach, a Catholic missionary organization
 * SPO:), a Lithuanian sports magazine
 * SPO Rouen Basket, a basketball club in Rouen, France
 * Scholarly Publishing Office, University of Michigan University Library
 * Seoul Philharmonic Orchestra, a South Korean orchestra based in Seoul
 * Strong Pareto optimum, in economics
 * Supreme Prosecutors' Office of the Republic of Korea
 * Erik Spoelstra, head coach of the Miami Heat
 * Sankt Peter-Ording, a tourist town in northern Germany