SUV39H1

Histone-lysine N-methyltransferase SUV39H1 is an enzyme that in humans is encoded by the SUV39H1 gene.

Function
This gene is a member of the suppressor of variegation 3-9 homolog family and encodes a protein with a chromodomain and a C-terminal SET domain. This nuclear protein moves to the centromeres during mitosis and functions as a histone methyltransferase, methylating lysine-9 of histone H3. Overall, it plays a vital role in heterochromatin organization, chromosome segregation, and mitotic progression. In mouse embryonic stem cells, Suv39h1 expression is repressed by OCT4 protein through the induction of an antisense long non-coding RNA.

Interactions
SUV39H1 has been shown to interact with:


 * CBX1,
 * CBX5,
 * DNMT3A,
 * HDAC1,
 * HDAC3,
 * HDAC9,
 * Histone deacetylase 2,
 * MBD1,
 * RUNX1,
 * Retinoblastoma protein,  and
 * SBF1.


 * PIN1