Saffo

Saffo may refer to:


 * Saffo (Mayr), 1794 opera by Mayr
 * Saffo (Pacini), 1840 opera by Pacini
 * Saffo in Leucade, by Francesco Morlacchi (1784-1841)
 * Paul Saffo (born 1954), American technology forecaster
 * Saffo the Greek, American organised crime figure, early 20th century
 * Saffo Music, 1977 album by Lara Saint Paul
 * Bill Saffo, Mayor of Wilmington, North Carolina