San Onofre

San Onofre or Santo Onofre may refer to:


 * Onuphrius, known as San Onofre in Spanish and Santo Onofre in Portuguese, 4th-century Egyptian hermit honored as a saint in the Roman Catholic Church
 * San Onofre, Sucre, a municipality in the Sucre Department of Colombia
 * San Onofre State Beach, located in San Diego County, California
 * San Onofre Nuclear Generating Station (SONGS), a nuclear power plant adjacent to the state beach
 * Caldas da Rainha — Santo Onofre e Serra do Bouro, one of the twelve civil parishes of Caldas da Rainha in Portugal
 * Santo Onofre River, in Brazil