San Tomé

San Tomé may refer to:


 * Rotonda di San Tomè, a church in northern Italy
 * San Tomé, Venezuela, a town in Anzoátegui, Venezuela
 * San Tomé de Angostura, one of the original names of the city Ciudad Bolivar, Venezuela
 * São Tomé and Príncipe, an island nation in the Gulf of Guinea
 * São Tomé Island, one of two islands and provinces in nation of São Tomé and Príncipe
 * São Tomé, the capital city of the island and province of São Tomé