Sanglifehrin

Sanglifehrin A is a polyketide natural product found to potently inhibit cyclophilins and have immunosuppressive activity.

History
Isolation and characterisation of Sanglifehrins, produced by fermentation of Streptomyces sp. A92-308110 was first published by JJ Sanglier and T Fehr in 1999.

Structure
Sanglifehrins are mixed polyketide / non-ribosomal peptides, and their biosynthesis requires a modular type I polyketide synthase, with one module of non-ribosomal peptide synthetase, which incorporates phenylalanine, later converted by a hydroxylase to meta-tyrosine.