Santa Cruz District

Santa Cruz District may refer to:


 * Peru:
 * Santa Cruz District, Alto Amazonas, in Alto Amazonas province, Loreto region
 * Santa Cruz District, Cutervo, in Cutervo province, Cajamarca region
 * Santa Cruz District, Huaylas, in Huaylas province, Ancash region
 * Santa Cruz District, Palpa, in Palpa province, Ica region
 * Santa Cruz District, Santa Cruz, in Santa Cruz province, Cajamarca region
 * Santa Cruz de Andamarca District, in Huaral province, Lima region
 * Santa Cruz de Chuca District, in Santiago de Chuco province, La Libertad region
 * Santa Cruz de Cocachacra District, in Huarochirí province, Lima region
 * Santa Cruz de Flores District, in Cañete province, Lima region
 * Santa Cruz de Toledo District, in Contumazá province, Cajamarca region
 * Costa Rica:
 * Santa Cruz District, León Cortés Castro, in León Cortés canton, San José province
 * Santa Cruz District, Santa Cruz, Guanacaste, in Santa Cruz canton, Guanacaste province
 * Santa Cruz District, Turrialba, in Turrialba canton, Cartago province