Santa Cruz River

Santa Cruz River or Rio Santa Cruz may refer to:

Rivers

 * Santa Cruz River (Argentina)
 * Santa Cruz River (Santa Catarina), Brazil
 * Santa Cruz River (Philippines)
 * Santa Cruz River (Arizona), Mexico and United States
 * Santa Cruz River (New Mexico), a tributary of the Rio Grande, in the United States
 * Santa Cruz River (Venezuela), see Aroa mines

Other uses

 * SS Rio Santa Cruz, an Argentinian steamship