Santiago Rodríguez

Santiago Rodríguez may refer to:
 * Santiago Rodríguez Masagó, Dominican military leader
 * Santiago Rodríguez Province, province of the Dominican Republic
 * Santiago Luis Polanco Rodríguez (born 1961), Dominican American former drug dealer
 * Santiago Rodriguez (pianist), Cuban musician
 * Santiago Rodríguez (footballer) (born 2000), Uruguayan footballer