Sean Hughes

Sean Hughes may refer to:
 * Sean Hughes (boxer) (born 1982), English boxer
 * Sean Hughes (comedian) (1965–2017), English-born Irish stand-up comedian, writer and actor
 * Sean Hughes (Irish republican), alleged IRA member
 * Sean Hughes (politician) (1946–1990), British Labour Party Member of Parliament, 1983–1990
 * Sean P. F. Hughes (born 1941), British emeritus professor of orthopaedic surgery
 * Sean Hughes, bassist with Green Day