Sean O'Brien

Sean O'Brien may refer to:

Sportspeople

 * Seán O'Brien (Gaelic footballer), Gaelic footballer for Nemo Rangers
 * Seán O'Brien (Cork hurler) (1926–?), Irish hurler
 * Seán O'Brien (Tipperary hurler), Irish hurler
 * Sean O'Brien (ice hockey) (born 1972), American former ice hockey left winger
 * Seán O'Brien (rugby union, born 1987), former Irish rugby union international flanker for Leinster and London Irish
 * Seán O'Brien (rugby union, born 1994), former Irish rugby union flanker for Connacht
 * Seán O'Brien (rugby union, born 1998), Irish rugby union centre / winger for Munster
 * Seán O'Brien (rugby union, born 2000), American-born Irish rugby union flanker for Connacht
 * Sean O'Brien (windsurfer) (born 1984), Australian windsurfer
 * Sean O'Brien (footballer), English footballer

Other people

 * Sean O'Brien (writer) (born 1952), British writer
 * Sean C. O'Brien, co-discoverer of buckminsterfullerene
 * Sean O'Brien (labor leader), American trade unionist
 * Sean O'Brien (musician), bassist and original member of Boston rock band Come
 * Sean O'Brien (Ohio politician) (born 1969), Democratic member of the Ohio Senate