Second Creek (Mississippi)

Second Creek is a waterway in the southern section of Adams County, Mississippi, United States. Second Creek is tributary to the Homochitto River. It enters the Homochitto near U.S. Route 61 bridge at Doloroso.

The Spanish explorer Hernando de Soto visited what is called White Apple Village, the settlement of Natchez chief Great Sun, along Second Creek, in approximately 1541. An attempted slave revolt, sometimes known as the Second Creek Slave Conspiracy, was suppressed in the vicinity of Second Creek in 1860.