Second St. Joseph Hotel

Second St. Joseph Hotel is a historic hotel building located at South Bend, St. Joseph County, Indiana. It was built in 1868, and is a three-story, Federal style brick building. It is the oldest extant commercial building in the city of South Bend. It was used as a hotel until 1876, after which it housed a variety of commercial enterprises. It is located next to the John G. Kerr Company building.

It was listed on the National Register of Historic Places in 1985.