South Carolina Highway 527

South Carolina Highway 527 (SC 527) is a 65.940 mi state highway in the U.S. state of South Carolina. It travels between Andrews on the Williamsburg–Georgetown county line to Lee County 6 mi south of Bishopville. The highway travels in a southeast–northwest direction.

Route description
SC 527 begins on the Williamsburg–Georgetown county line north of Andrews at SC 41. It travels northwest to Williamsburg County's seat, Kingstree where it has a brief concurrency with U.S. Route 52 (US 52). Continuing northwest into Clarendon County, it intersects US 301 and Interstate 95 (I-95) but does not pass through any incorporated municipalities in this county. It then cuts through the eastern panhandle of Sumter County, again not passing through any incorporated towns. It does intersect US 378 at the approximate midpoint through this county. SC 527 as it enters Lee County heads in a more northerly course where it intersects U.S. Routes 76 and 401. The highway ends in the unincorporated community of Wisacky, 6 mi south of Bishopville at SC 341.

Kingstree connector route
South Carolina Highway 527 Connector (SC 527 Conn.) is a 0.290 mi connector route of SC 527. Its entire length is unsigned. It utilizes a brief segment of Thurgood Marshall Highway in Kingstree from the SC 527 mainline to SC 377.