South Central Conference

South Central Conference may refer to:


 * South Central Conference (California), junior college athletic conference in California formed in 1948
 * South Central Conference (Illinois), high school athletic conference in Illinois formed in 1926
 * South Central Conference (Indiana), high school athletic conference in Indiana from 1936 to 1997
 * South Central Conference (Iowa), high school athletic conference in Iowa formed in 1930
 * South Central Athletic Conference, college athletic conference of historically black colleges and universities (HBCUs) from 1935 to 1961