Southern Discomfort

Southern Discomfort may refer to:


 * Southern Discomfort (Rita Mae Brown novel), a novel released in 1982 by Rita Mae Brown
 * Southern Discomfort (Eyehategod album), an album released in 2000 by sludge metal band Eyehategod
 * Southern Discomfort (Rehab album), is an album released in 2000 by rock band Rehab
 * Southern Discomfort (Fabian Society pamphlets), a series of pamphlets that examined attitudes to the British Labour Party in the south of England
 * Southern Discomfort Roller Derby, a men's roller derby league based in London
 * "Southern Discomfort", an episode of the seventh season of The Real Housewives of Atlanta, an American reality television series