Southworth House

Southworth House may refer to:


 * Southworth House (Greenwood, Mississippi), listed on the National Register of Historic Places in Leflore County, Mississippi
 * Southworth House (Dryden, New York), listed on the NRHP in Tompkins County, New York
 * Southworth House (Cleveland, Ohio), listed on the NRHP in Cuyahoga County, Ohio