Spen

Spen may refer to:


 * SPEN, human gene
 * S.P.E.N., Secret sof
 * Spen, West Yorkshire, a location in England
 * River Spen, river in West Yorkshire, England, the United Kingdom
 * SS Spen, British steamship built in 1908
 * Spen Whittaker (1871–1910), English football manager
 * SP Energy Networks, the energy networks arm of Scottish Power