Spofford

Spofford may refer to:
 * Spofford, New Hampshire
 * Spofford Lake
 * Spofford Juvenile Center, New York City
 * Spofford, Texas
 * Spofford (play), a 1967 play

People with the surname

 * Ainsworth Rand Spofford (1825–1908), Librarian of Congress, 1864–1897
 * Charles Spofford (1902–1991), lawyer
 * Edward Spofford, American professor of literature
 * Harriet Elizabeth Prescott Spofford (1835–1921), American writer
 * Henry M. Spofford (1821–1880), 19th-century Louisiana politician
 * Sally Hoyt Spofford (1914–2002), American ornithologist
 * William B. Spofford (1921–2013), Episcopal bishop